In detail, we review the discovery of tls polymerases and describe the molecular features of all the mammalian tls polymerases identified so far. We give a short overview of the mechanisms that regulate the selectivity and activity of tls polymerases. In addition, we summarize the current knowledge how different types of dna damage, relevant either for the induction or treatment of cancer, are bypassed by tls polymerases. Finally, we elucidate the relevance of tls polymerases in the context of cancer therapy. Keywords, proliferate cell Nuclear AntigenBypass reactionbrct domainPost Replicative repairChicken DT40 Cell. Dna damage response (ddr genomic information is stored as deoxyribonucleic acid (DNA) in every living organism and needs to be protected and maintained to guarantee genomic integrity.
Dna synthesis - biology-Online dictionary
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New dna synthesis Method could soon build a genome in a day
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Dna synthesis - an overview ScienceDirect Topics
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